單位：獸醫學院　　　獸醫學系

教師姓名：周濟眾

職稱：副教授

Name：Chou, Chi-Chung

E-mail：ccchou@nchu.edu.tw

TEL：886-4-22840404 ext 177 or 219

FAX：886-4-22862073

最高學位：美國佛羅里達大學哲學博士

學歷(Education)：

    美國佛羅里達大學哲學博士（Ph. D., University of Florida, USA）
    國立中興大學獸醫學碩士（M. S., National Chung-Hsing University）
    國立中興大學獸醫學學士（B. S., National Chung-Hsing University）

經歷(Professional Experiences)：

    國立中興大學獸醫系助理教授（Assistant Professor, National Chung-Hsing University）
    美國北卡蘿萊納州立大學副研究員（Research Associate, Center for Chemical  Toxicology    

        Research and Pharmacokinetics, NC State University, USA）
    美國佛羅里達大學研究助理（Research Assistant, University of Florida, USA）

考試(Certification)：

專長(Specialty)：

    藥物分析（Analytical Pharmacology）

    藥物動力學（Pharmacokinetics）

研究領域(Areas of Interest)： 

1.      Development of HPLC and CE Methods for Biomedical Applications

2.      Application of chemical analysis to public health

主要教授課程(含大學部及研究所) Major Courses Taught：

1. Clinical Pathology

2. Principle Pharmacokinetics

3. Veterinary Public Health

4. Environmental Toxicology

著作目錄 (Publication List)：

Ａ、期刊論文 (Peer Reviewed Publications)

1. Yang, C. W., Zen, J. M., Gau, Y. L. Hsu, C. T., Chung, T. C. and Chou, C. C*. (2007) Profiling of Urolithic Organic Acids in Human and Canine Urolithiasis with Electrochemical Detection using Copper Nanoparticle Plated Electrodes. J Chromatography B Analyt Technol Biomed Life Sci. (In Revision, JCB-06-353)

2. Vickroy, T.W., Chang, S. K., and Chou, C. C.* (2007) Caffeine-induced hyperactivity in the horse: Comparisons of drug and metabolite concentrations in blood and cerebrospinal fluid (CSF). Journal of Veterinary Pharmacology and Therapeutics (accepted) (SCI, IF=1.406)

3. Yeh, L. C., Lee, W. M., Koh, B. W., Chan, J. P. W., Liou, C. H., Kao J. P. and Chou, C. C.* (2007) Development of amoxicillin enzyme-linked immunosorbent assay and measurements of tissue amoxicillin concentrations in a pigeon microdialysis model. Poultry Science (accepted) (SCI, IF=1.656)

4. Tung, K. C., Liu, J. S., Cheng, F. P., Yang, C. H., Tu, W. C., Wang, K. S., Shyu, C. L., Lai, C. H., Chou, C. C. and Lee, W. M. (2007) Study on the species-specificity of Isospora michaelbakeri by experimental infection Acta Vet. Hung. vol 55 (1): 77-85 (SCI, IF=0.541)

5. Chou, C. C., Lin, S. P., Lee, K. M., Hsu, C. T., Vickroy, T. W. and Zen, J. M. (2007) Fast Differentiation of Meats from Fifteen Animal Species by Liquid Chromatography with Electrochemical Detection using Copper Nanoparticle Plated Electrodes. J Chromatogr B Analyt Technol Biomed Life Sci. 846(1-2):230-239 (SCI, IF=2.647)

6. Chang, M. H., Lo, D. Y., Chou, C. C. and Lee, W. M. (2006) Distribution of carbonic anhydrase in digestive tract of Pond loach (Misgurnus anguilicaudatus). Journal of Veterinary Medical Science Vol. 68 (9):1009-1011 (SCI, IF=0.827)

7. Lin, S. Y., Lai, W.W., Chou, C. C., Kuo, H. M., Li, T. M., Chung, J. G. and Yang, J. H. (2006) Sodium ascorbate inhibits the growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells. Melanoma Research 16(6):509-519 (SCI, IF=1.704)

8. Chou, C. C. *, Yang, J. H., Chen, S. D., Monteiro-Riviere, N. A., Li, H. N. and Chen, J. J. W. (2006) Expression Profiling of Human Epidermal Keratinocyte Response Following One-Minute JP-8 Exposure. Cutaneous and Ocular Toxicology 25(2):141-153. (SCI, IF=0.273)

9. Mao, C. L., Zientek, K.D, Colahan, P. T., Kuo, M. Y., Liou, C. H., Lee, K.M. and Chou, C. C.* (2006) Development of an Enzyme-Linked Immunosorbent Assay for Fentanyl and Application of Fentanyl Antibody-Coated Nanoparticles for Sample Preparation. Journal of Pharmaceutical and Biomedical Analysis 16;41(4):1332-1341 (SCI, IF=2.032)

10. Yang, J. H., Lee, C. H., Monteiro-Riviere, N. A., Riviere, J. E., Tsang, C. L. and Chou, C. C.* (2006) Toxicity of Jet Fuel Aliphatic and Aromatic Hydrocarbon Mixtures on Human Epidermal Keratinocytes: Evaluation based on In vitro Cytotoxicity and Interleukin-8 Release. Archives of Toxicology 80(8):508-523 (SCI, IF=1.787)

11. Yang, J. H., Hsia, T. C., Kuo, H. M., Chao, P. L., Chou, C. C., Wei, Y. H. and Chung, J. G. (2006) Inhibition of Lung Cancer Cell Growth by Quercetin Glucuronides via G2/M Arrest and Induction of Apoptosis. Drug Metabolism and Disposition 34:296-304 (SCI, IF=3.831)

12. 陳三多,周濟眾,周明智,William Bell,曾楨皓,楊仁宏 (2004) Terbinafine 臨床治療劑量對大白鼠肝臟的病理作用 中華皮膚科醫學雜誌 22(4):274-280

13. Yang, J. H., Chou, C. C., Cheng, Y. W., Sheen, L. Y., Chou, M. C., Yu, H. S., Wei, Y. H., Chung, J. G. (2004) Effects of glycolic acid on the induction of apoptosis via caspase-3 activation in human leukemia cell line (HL-60). Food and Chemical Toxicology 42: 1777-1784. (SCI, IF=2.393)

14. Chou, C. C., Riviere J. E. and. Monteiro-Riviere N. A. (2003) The cytotoxicity of Jet fuel aromatic hydrocarbons and dose related IL-8 release from human epidermal keratinocytes. Archives of Toxicology (77):384-391(SCI, IF=1.787)

15. Chou, C. C. and Vickroy, T. W. (2003) Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. American Journal of Veterinary Research 64(2):216-24 (SCI IF=1.241)

16. Chou, C. C., Riviere J. E. and. Monteiro-Riviere N. A. (2002) Differential relationship between the carbon chain-length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity versus interleukin-8 release in human epidermal keratinocytes. Toxicological Science 69(1):226-33 (SCI, IF=3.391)

17. Chou, C. C., Chen, C. L., Rice B. L. and Colahan, P. T. (2002) Reduced resident time and pharmacodynamic effects of acepromazine after subclinical multiple dosage in exercised Thoroughbreds. Journal of Veterinary Pharmacology and Therapeutics. 25(5):379-82 (SCI, IF=1.230)

18. Colahan, P. T., Bailey, J. E., Chou, C. C., Johnson, M., Rice, B. L., Jones, G. L. and Cheeks J. P. (2002) Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned Thoroughbred horses subjected to an incremental exercise stress test. Veterinary Therapeutics. Vol. 3, No. 1. 37-48 (SCI)

19. Colahan, P. T., Bailey, J. E., Johnson, M., Rice, B. L., Chou, C. C., Cheeks J. P. Jones, G. L., and Yang M. (2002) Effect of sulfadiazine and pyrimethamine on selected physiologic and performance parameters in athletically conditioned Thoroughbred horses during an incremental exercise stress test. Veterinary Therapeutics. Vol. 3, No. 1. 49-63(SCI)

20. Chou, C. C., Webb A. I., Brown M. P., Gronwall R. and Vickroy, T. W. (2001) Continuous measurement of caffeine and two metabolites in blood and skeletal muscle of unrestrained adult horses by semi-automated in vivo microdialysis Journal of Veterinary Pharmacology and Therapeutics. 24:405-414 (SCI, IF=1.230)

21. Chou, C. C.*, Brown, M. P. and Merrit, K. A. (2000) Capillary zone electrophoresis for the determination of Atovaquone in serum. Journal of Chromatography B. 742:441-445 (SCI, IF=2.793)

22. Chou, C. C., Chen, C. L., Asbury, A. C., Webb, A. I. and Vickroy, T. W. (1998) Development and use of an enzyme-linked immunosorbent assay to monitor serum and urine acepromazine concentrations in Thoroughbreds, and possible changes associated with exercise. American Journal of Veterinary Research. 59: 593-597 (SCI, IF=1.182)

23. 周濟眾 (1994) 敗血性巴氏桿菌 (Pasteurella multocida) 與猪肺炎之相關性研究 臺灣畜牧獸醫學會會報 (64):31-42

B、期刊論文 (Supplement Issues)

1. Chou, C. C., Lin, S. P. Lee, K. M. Hsu, C. T. and Zen, J. M. (2006) Fast Identification of Meats from Fifteen Animal Species by Liquid Chromatography with Electrochemical Detection using Copper Nanoparticle Plated Electrodes. Toxicological Sciences, 90(S-1):447 (SCI, IF=3.391)

2. Chou, C. C., Yang, J.H., Monteiro-Riviere N.A., Chen, J.W. (2005) Expression profiling of human epidermal keratinocytes response following JP-8 exposure. Toxicological Sciences, 84(S-1):447 (SCI, IF=3.391)

4. Chou, C. C., Riviere J. E. and. Monteiro-Riviere N. A. (2002) Differential relationship between the carbon chain-length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity versus interleukin-8 release in human epidermal keratinocytes. Toxicological Science 69(1):226-33 (SCI, IF=3.391)

5. Monteiro-Riviere, N. A., Chou, C. C. and Riviere J. E. (2003) The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes. Toxicological Sciences, 72(S): 383 (SCI, IF=3.391)

6. Chou, C. C., Monteiro-Riviere, N. A. and Riviere, J. E. (2002) Assessment of cytotoxicity of aliphatic and aromatic hydrocarbons exposed to human epidermal keratinocytes. Toxicological Sciences, 66(1-S): 163 (SCI, IF=3.391)

C、研討會論文 (Posters)

國外 (International):

1. Chou, C. C.*, Huang, Y. J., Shyu, C. L., Liao, J. W. and Chang, S. K. Heat stability of antibiotics characterized by changes in chromatographic profiles, ultraviolet spectrometry, antimicrobial activity and genotoxicity. 47th Society of Toxicology (SOT) annual symposium, Seattle, WA, USA, 2008.

2. Chou, C. C.*, Lin, Y. C., Lee, W. M., Hung, C. J., and Zen, J. M. Detection of Zeranol and Metabolic Analogs in moldy food by Liquid Chromatography with Electrochemical detection Containing Screen-Plated Disposable Electrodes 46th Society of Toxicology (SOT) annual symposium, Charlotte, NC, USA, 2007.

3. Chou, C. C., Lin, S. P. Lee, K. M. Hsu, C. T. and Zen, J. M. Fast Identification of Meats from Fifteen Animal Species by Liquid Chromatography with Electrochemical Detection using Copper Nanoparticle Plated Electrodes. 45th Society of Toxicology (SOT) annual symposium, San Diego CA, USA, 2006.

4. Chou, C. C., Yang, J. H. Monteiro-Riviere N. A and Chen, J. J. W. Expression profiling of human epidermal keratinocytes response following JP-8 exposure. 44th Society of Toxicology (SOT) annual symposium, New Orleans LA, USA, 2005.

6. Monteiro-Riviere N. A., Chou C. C. and Riviere J. E.: Dose related interleukin-8 release from epidermal keratinocytes after exposure to jet fuel aromatic hydrocarbons. Proceedings of the 9th International Congress of the European Association for Veterinary Pharmacology and Toxicology. p.162, 2003.

7. Monteiro-Riviere, N. A., Chou, C. C. and Riviere J. E. The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes. #1859, p383. 42nd Society of Toxicology (SOT) annual symposium, Salt Lake City, UA, 2003.

8. Chou, C. C., Monteiro-Riviere, N. A. and Riviere, J. E. Assessment of cytotoxicity of aliphatic and aromatic hydrocarbons exposed to human epidermal keratinocytes. #791 p.163. 41st Society of Toxicology (SOT) annual symposium, Nashville, TN, 2002.

9. Chou, C. C., Monteiro-Riviere, N. A. and Riviere, J. E. Differential relationship between the carbon chain-length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity versus interleukin-8 release in human epidermal keratinocytes, 7th Society of Environmental Toxicology and Chemistry (SETAC) annual symposium, Raleigh, NC, 2002.

10. Colahan, P.T., Ford, P., Chou, C.C., Johnson, M, Rice, B. L. and Jackson, C. The elimination of caffeine origination from human food sources from athletically conditioned Thoroughbred horses as determined by ELISA analysis. Proceedings of the International Conference of Racing Analysts and Veterinarians 14th Annual Meeting, Orlando, Florida. (2002)

11. Chou, C. C., Brown, M. P. and Merrit, K. A. Capillary zone electrophoresis for the determination of Atovaquone in serum. The 12th international symposium on high performance capillary electrophoresis (HPCE), Anaheim, CA, 1999.

國內 (National):

1. 馬滋憶、周濟眾。以毛細管電泳搭配雷射螢光偵測ppb等級四環素類抗生素殘留。96年度中華民國畜牧獸醫年會秋季學術研討會。國立中興大學獸醫學院。2007/12/22

2. 洪奇正、郭旭英、周濟眾。以液相層析搭配奈米銅電極區分鴕鳥肉、雞肉、牛肉以及猪肉之研究。96年度中華民國畜牧獸醫年會秋季學術研討會。國立中興大學獸醫學院。2007/12/22

3. 鄭佳妮、沈瑞鴻、黃俊仁、周濟眾。建立家禽微透析模式以研究Florfenicol在雞之組織動力學及殘留。95年度中華民國畜牧獸醫年會秋季學術研討會。國立中興大學獸醫學院。2006/12/14

4. 楊竣惟、徐振騰、曾志明、周濟眾。以HPLC-EC比較正常與結石尿中有機酸濃度差異之研究。94年度中華民國畜牧獸醫年會秋季學術研討會。國立中興大學獸醫學院。2005/12/14

5. 師維孝、洪奇正、徐振騰、曾志明、周濟眾。以HPLC-EC偵測台灣地區Zeranol及其代謝產物之殘留。94年度中華民國畜牧獸醫年會秋季學術研討會。國立中興大學獸醫學院。2005/12/14

6. 李國閔、郭美月、劉其和、鄭佳妮、周濟眾。多用途微粒免疫酵素聯結 反應之開發與應用。94年度春季學術研討會。國立屏東科技大學。2005/5/14

7. 李國閔、林琇蘋、徐振騰、曾志明、周濟眾。以高效能液相層析結合奈米銅電極鑑定肉品種別之研究。94年度春季學術研討會。國立屏東科技大學。2005/5/14

8. 李家卉、周濟眾。混合JP-8中主要脂肪族與芳香族碳氫化合物對人類表皮角質細胞毒性之探討。93年度聯合年會暨學術論文發表會。國立台灣大學農學院附設動物醫院。2004/12/18

9. 葉俐君、周濟眾。Amoxicillin免疫酵素聯結反應試劑之開發與應用。92年度聯合年會暨學術論文發表會。國立中興大學獸醫學院。2003/12/

D. 專書 (Books):

1. 周濟眾。獸醫實驗診斷學-診斷與評估 (2007) (譯自Denny Meyer and John rvey, Veterinary Laboratory Medicine- Interpretation and Diagnosis 04)。由美商Saunders及Elsevier Ltd.授權。

E、技術報告 (Book Chapter and Technical Reports)

1. Colahan, P., Chou, C. C., Johnson, M., Rice, B. and Cheek, J. (1998) Effects of sulfadiazine/pyrimethamine and exercise on selected physiological and performance parameters in athletically conditioned Thoroughbred horses. Final Technical Report to the Division of Pari-Mutuel Wagering, State of Florida, USA.

2. Colahan, P., Chou, C. C., Johnson, M., Boules, B., Rice, B. and Kubilis, P. (1997) The combined effect of Prednisolone and exercise on some physiological parameters in Thoroughbreds. Final Technical Report to the Division of Pari-Mutuel Wagering, State of Florida, USA.

parameters in Thoroughbreds. Final Technical Report to the Division of Pari-Mutuel Wagering, State of Florida, USA.

F、譯作 (Translated Articles)

1. Norris D. E.,宋華聰,李進咸,林鼎翔,周濟眾,師健民,陳豪勇,陳雨新,劉振軒,顏哲傑. Lyme disease in the United States and vector identification. (2002) 人畜共通傳染病研討會論文集. 行政院農業委員會動植物防疫檢疫局,衛生署疾病管制局.

2. Chou C. C. and Huang W. Y. (1997) Use of NZB/W mice as an animal model for the study of Proliferative Lupus Nephritis. Newsletter of National Laboratory Animal Breeding Research Center, National Science Council, Taiwan. Vol. 4, No. 4: 27-28

3. Chou C. C. and Huang W. Y. (1996) Use of Sprague-Dawley Rat as an animal model for the study of infectious Struvite Urinary Lithiasis. Newsletter of National Laboratory Animal Breeding & Research Center, National Science Council, Taiwan. Vol. 4, No. 2: 22-23

G. 專利 (Patent)

1. 用於肉品種別及新鮮度鑑定之HPLC-EC(高效能液相層析術結合電化學分析)測定方法 (國內專利申請中，9513-0151，Patent pending)

H. 獎勵 (Awards)

1. 論文Fast Differentiation of Meats from Fifteen Animal Species by Liquid Chromatography with Electrochemical Detection using Copper Nanoparticle Plated Electrodes. J Chromatogr B Analyt Technol Biomed Life Sci. 獲化學分析專業網頁SeparationsNow.com (John Wiley & Sons Ltd.)專文報導，題目為”One kebab, but hold the pigeon” (http://www.separationsnow.com/coi/cda/detail.cda?id=15083&type=Feature&chId=7&page=1)

2. 論文Expression Profiling of Human Epidermal Keratinocyte Response Following One-Minute JP-8 Exposure.獲Cutaneous and Ocular Toxicology 期刊選為2006年年度最佳論文。並於2007年世界毒理學年會(Society of Toxicology)中頒獎。

3. 95年度中興大學建教合作計劃績優教師

4. 95學年度中興大學獸醫學院教學及服務獎勵教師

I、會員 (Professional Membership)：

1. Member of Society of Toxicology (SOT) Since 2002
2. Member of Poultry Science Association (PSA) Since 2008

J、近年執行計劃 (Grants)：